unspecified interaction mechanism. Exercise extreme caution when vilanterol coadministered with drugs that prolong QTc interval; adrenergic agonist effects on the cardiovascular system may be potentiated. Use Caution/Monitor. These results are consistent with the conclusion from another published review (Krousel-Wood et al 2004). Monitor closely for signs of respiratory depression and sedation. Seventy-one percent of the patients who had symptoms reduced the use of sodium, as compared to only 7% of the patients who did not suffer from symptoms (Kyngas and Lahdenpera 1999). Monitor Closely (1)apalutamide will decrease the level or effect of acetaminophen by increasing elimination. Contraindicated. Sep. by 24h. Serious - Use Alternative (1)tacrolimus and temsirolimus both increase immunosuppressive effects; risk of infection. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Minor/Significance Unknown. Monitor Closely (1)quinupristin/dalfopristin will increase the level or effect of tacrolimus by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. prescription products. ezogabine, tacrolimus. Dronabinol is highly bound to plasma proteins and may displace and increase the free fraction of other concomitantly administered highly protein-bound drugs. Comment: OATP1B1 inhibitors may increase risk of myopathy. Use Caution/Monitor.Minor (1)primidone decreases levels of acetaminophen by increasing metabolism. Monitor Closely (1)metoclopramide intranasal will increase the level or effect of tacrolimus by Other (see comment). Future studies need to address this interaction issue, as this may be crucial to reducing the level of non-compliance in general, and to enhancing the possibility of achieving the desired healthcare outcomes. Serious - Use Alternative (1)fentanyl transdermal, oxycodone. Voxelotor increases systemic exposure of sensitive CYP3A4 substrates. Avoid coadministration with sensitive CYP3A substrates. Similarly, a meta-analysis found that there was a significant difference in compliance rate between patients taking antihypertensive medication once daily and twice daily (92.1% and 88.9%, respectively) (Iskedjian et al 2002). Osterberg L, Blaschke T. Adherence to medication. Monitor Closely (1)methylergonovine, lurasidone. Minor/Significance Unknown. Interaction mainly occurs in preterm infants. Your list will be saved and can be edited at any time. Avoid or Use Alternate Drug.tacrolimus and erythromycin base both increase QTc interval. Use Caution/Monitor. Effect of interaction is not clear, use caution. Telotristat ethyl induces CYP3A4 and may reduce systemic exposure of sensitive CYP3A4 substrates. enzalutamide decreases levels of oxycodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Consult your doctor for specific instructions. Caution with narrow therapeutic index drugs that are highly protein bound when initiating or increasing the dose of dronabinol. Use Caution/Monitor. Monitor Closely (1)oxycodone and protriptyline both increase sedation. These desired outcomes are part and parcel of the objectives in the management of the diseases or conditions. Use Caution/Monitor.Serious - Use Alternative (1)rifampin will decrease the level or effect of tacrolimus by affecting hepatic/intestinal enzyme CYP3A4 metabolism. oxycodone and apomorphine both increase sedation. Monitor Closely (2)tacrolimus will increase the level or effect of risperidone by P-glycoprotein (MDR1) efflux transporter. Mechanism: pharmacodynamic synergism. alvimopan, oxycodone. Oxycodone may enhance the neuromuscular blocking action of true skeletal muscle relaxants and produce an increased degree of respiratory depression. Minor/Significance Unknown. Monitor Closely (1)etravirine will decrease the level or effect of tacrolimus by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serious - Use Alternative (1)tacrolimus, axicabtagene ciloleucel. Contraindicated. Hydromorphone (<3% of the circulating parent hydrocodone [benzhydrocodone is prodrug of hydrocodone]) is mainly formed by CYP2D6 mediated O-demethylation of hydrocodone. Comment: Caution when bowel preps are used with drugs that cause SIADH or NSAIDs; increased risk for water retention or electrolyte imbalance. Use Caution/Monitor. Minor/Significance Unknown. celecoxib will increase the level or effect of nebivolol by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)polymyxin B and tacrolimus both increase nephrotoxicity and/or ototoxicity. Idelalisib is a strong CYP3A inhibitor; avoid coadministration with sensitive CYP3A substrates. [23], A 2020 Cochrane systematic review did not find enough evidence of reduction of all-cause mortality, serious adverse events, cardiovascular mortality, non-fatal myocardial infarction, non-fatal stroke or end-stage renal disease when comparing metformin monotherapy to dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes. Either increases toxicity of the other by sedation. tacrolimus decreases effects of influenza virus vaccine trivalent by pharmacodynamic antagonism. In others, gradually tapering a patient off of a prescribed benzodiazepine or other CNS depressant or decreasing to the lowest effective dose may be appropriate. Use Caution/Monitor. Either increases toxicity of the other by pharmacodynamic synergism. Serious - Use Alternative (1)methylergonovine, yohimbine. quercetin will decrease the level or effect of tacrolimus by P-glycoprotein (MDR1) efflux transporter. Use Caution/Monitor. Use Caution/Monitor. tacrolimus decreases effects of measles, mumps, rubella and varicella vaccine, live by pharmacodynamic antagonism. Use Caution/Monitor. Rubin RR. Minor (1)levoketoconazole will increase the level or effect of celecoxib by affecting hepatic enzyme CYP2C9/10 metabolism. Modify Therapy/Monitor Closely. Additive vasospasm; risk of hypertension. Manage and view all your plans together even plans in different states. Use Caution/Monitor. Minor/Significance Unknown. Effect of interaction is not clear, use caution. Minor/Significance Unknown. Monitor tacrolimus levels and adjust dose accordingly. Prescribing medication with non-invasive route of administration (eg, oral medication) and simple dosing regimens might motivate patients to be compliant. Use Caution/Monitor. venlafaxine decreases effects of oxycodone by decreasing metabolism. Use Caution/Monitor. celecoxib decreases effects of losartan by pharmacodynamic antagonism. tacrolimus will increase the level or effect of saquinavir by P-glycoprotein (MDR1) efflux transporter. Opioids may enhance the serotonergic effects of SSRIs and increase risk for serotonergic syndrome. prednisone will decrease the level or effect of tacrolimus by affecting hepatic/intestinal enzyme CYP3A4 metabolism. For instance, a shampoo is a cosmetic, since its intended use is to cleanse the hair. Use Caution/Monitor.Minor (1)aspirin rectal will increase the level or effect of celecoxib by acidic (anionic) drug competition for renal tubular clearance. Avoid or Use Alternate Drug. celecoxib increases and salmeterol decreases serum potassium. Avoid or Use Alternate Drug. tacrolimus decreases effects of BCG vaccine live by pharmacodynamic antagonism. Use Caution/Monitor. Avoid coadministration of sensitive CYP3A4 substrates with ivosidenib or replace with alternative therapies. Minor/Significance Unknown. Other (see comment). Ibrutinib may increase the risk of hemorrhage in patients receiving antiplatelet or anticoagulant therapies and monitor for signs of bleeding. By clicking send, you acknowledge that you have permission to email the recipient with this information. Concomitant therapy is expected to increase the risk of immunosuppression. Profound sedation, respiratory depression, coma, and death may result if coadministered. Minor (1)celecoxib increases levels of vancomycin by decreasing renal clearance. To view formulary information first create a list of plans. Use Caution/Monitor. Separate by 2 hours. Avoid or Use Alternate Drug. Use Caution/Monitor. Comment: Concomitant administration increases risk of nephrotoxicity. Either increases toxicity of the other by pharmacodynamic synergism. Serious - Use Alternative (1)amisulpride and tacrolimus both increase QTc interval. imatinib increases levels of oxycodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Serotonin modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic malignant syndrome. duvelisib will increase the level or effect of oxycodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. haloperidol and tacrolimus both increase QTc interval. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals.Serious - Use Alternative (1)celecoxib, quinapril. celecoxib increases effects of tolbutamide by unknown mechanism. ritonavir increases levels of methylergonovine by decreasing metabolism. Use Caution/Monitor. The use of dronedarone in combination with other medications that can prolong the QT interval is considered contraindicated. However, one alarming observation is that non-compliance remains a major issue in enhancing healthcare outcomes in spite of the many studies highlighting the problem over the years. Oxycodone may enhance the neuromuscular blocking action of true skeletal muscle relaxants and produce an increased degree of respiratory depression. crofelemer increases levels of tacrolimus by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Either increases effects of the other by anticoagulation. Decreased conversion of oxycodone to active metabolite morphine. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction). Minor (1)disulfiram will increase the level or effect of acetaminophen by affecting hepatic enzyme CYP2E1 metabolism. Patal RP, Taylor SD. Monitor Closely (1)celecoxib will increase the level or effect of probenecid by acidic (anionic) drug competition for renal tubular clearance. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs that are CYP3A4 substrates can result in lower exposure to these medications. Use Caution/Monitor. ketoconazole will increase the level or effect of celecoxib by affecting hepatic enzyme CYP2C9/10 metabolism. This document does not contain all possible drug interactions. Modify Therapy/Monitor Closely. rivastigmine increases toxicity of celecoxib by pharmacodynamic synergism. Similarly, a longer duration of treatment period might also compromise patients compliance (Menzies et al 1993; Ghods and Nasrollahzadeh 2003; Dhanireddy et al 2005). Modify Therapy/Monitor Closely. Use Caution/Monitor. Additive analgesia. Use Caution/Monitor. Monitor Closely (1)tacrolimus will increase the level or effect of maraviroc by P-glycoprotein (MDR1) efflux transporter. methylergonovine decreases effects of nitroglycerin transdermal by pharmacodynamic antagonism. Use Caution/Monitor. Contraindicated. Use Caution/Monitor.tacrolimus increases toxicity of simvastatin by Other (see comment). Contraindicated. Use Caution/Monitor. Interrupt dosing in all patients taking NSAIDs with long elimination half-lives for at least 5d before, the day of, and 2d following pemetrexed administration. Monitor Closely (1)oxycodone increases effects of pancuronium by unspecified interaction mechanism. Comment: Pretomanid regimen associated with hepatotoxicity. unspecified interaction mechanism. SIDE EFFECTS: Headache, nausea, vomiting, or dizziness may occur. Kyngas H, Lahdenpera T. Compliance of patients with hypertension and associated factors. Opioids may enhance the serotonergic effects of SSRIs and increase risk for serotonergic syndrome. Additive vasospasm. minocycline, methylergonovine. methylergonovine, risperidone. Avoid or Use Alternate Drug. Monitor for hypotension, respiratory depression, and profound sedation. In hypertensive patients, poor compliance with therapy is the most important reason for poorly controlled blood pressure, thus increasing the risk of stroke, myocardial infarction, and renal impairment markedly. Monitor therapeutic drug concentrations and adjust the dose as needed. Increased serum asparate aminotransferase concentration, Known hypersensitivity (eg, anaphylactic reactions, serious skin reactions) to celecoxib or its components, History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs; severe, sometimes fata, anaphylactic reactions reported, In the setting of coronary artery bypass graft, Demonstrated allergic-type reactions to sulfonamides, Increased risk of adverse cardiovascular events and skin reactions, Caution in asthma (bronchial), bleeding disorder, bronchospasm, duodenal/gastric/peptic ulcer, renal impairment, Risk of GI bleeding, ulceration, and perforation; factors that increase risk of GI bleeding in patients treated with NSAIDs include longer duration of NSAID therapy; concomitant use of oral corticosteroids, antiplatelet drugs (such as aspirin), anticoagulants; or selective serotonin reuptake inhibitors (SSRIs); smoking; use of alcohol; older age; and poor general health status, Long-term administration of NSAIDs may result in renal papillary necrosis and other renal injury; patients at greatest risk include elderly individuals; those with impaired renal function, hypovolemia, heart failure, liver dysfunction, or salt depletion, and those taking diuretics, angiotensin-converting enzyme inhibitors, or angiotensin-receptor blockers, Anemia may occur; monitor hemoglobin or hematorcrit in long term treatment patients, Use caution in pediatrics with systemic-onset juvenile idiopathic arthritis; serious adverse reactions, including disseminated intravascular coagulation reported, NSAIDs may cause serious skin reacitons including exfoliative dermatitis, Stevens-Johnson syndrome, and toxic epidermal necrolysis, may occur without warning or without prior known sulfa allergy; discontinue at first sign of rash, There are no adequate and well-controlled studies on pregnant women; data from observational studies regarding potential embryofetal risks of NSAIDs during the 1st or 2nd trimesters are inconclusive, Limited data from 12 breastfeeding women showed low levels of celecoxib in breast milk, Calculated average daily infant dose was 10-40 mcg/kg/day, <1% of the weight-based therapeutic dose for a 2-year old child, There is no information available regarding effects of drug on milk production; the developmental and health benefits of breastfeeding should be considered along with mothers clinical need for therapy and any potential adverse effects on breastfed infant from drug or from underlying maternal condition. celecoxib decreases effects of phenoxybenzamine by pharmacodynamic antagonism. Immunosuppressive drugs may reduce the immune response to influenza vaccine. Monitor Closely (1)dexmedetomidine and oxycodone both increase sedation. Use Caution/Monitor. nefazodone, celecoxib. fenoprofen, tacrolimus. celecoxib decreases effects of azilsartan by pharmacodynamic antagonism. Dietrich AJ, Oxman TE, Burns MR, et al. Monitor for increased concentrations or toxicities of sensitive CYP substrates. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction). celecoxib and dong quai both increase anticoagulation. Monitor Closely (1)celecoxib and dong quai both increase anticoagulation. Monitor Closely (1)pentobarbital will decrease the level or effect of tacrolimus by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Sep. by 24h. Use Caution/Monitor. armodafinil will decrease the level or effect of tacrolimus by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely. Use Caution/Monitor. Serious - Use Alternative (1)saquinavir increases levels of oxycodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Serious - Use Alternative (1)methylergonovine, methylphenidate. Avoid or Use Alternate Drug. Avoid or Use Alternate Drug. Noncompliance in organ transplant recipients. Use Caution/Monitor. Serious - Use Alternative (1)methylergonovine, propylhexedrine. pharmacodynamic antagonism. sodium citrate/citric acid decreases levels of celecoxib by inhibition of GI absorption. Use Caution/Monitor. Serious - Use Alternative (1)tacrolimus decreases effects of hepatitis a/typhoid vaccine by pharmacodynamic antagonism. Either increases toxicity of the other by Other (see comment). Potential for increased risk of bleeding, caution is advised. Coadministration may result in hypotension, profound sedation, respiratory depression, coma, and death. Minor (1)oxycodone and eucalyptus both increase sedation. This information is not individual medical advice and does not substitute for the advice of your health care professional. Minor/Significance Unknown. Comment: Concomitant administration can increase the potential for CNS effects (e.g., increased sedation or respiratory depression). Immunosuppressive drugs may reduce the immune response to influenza vaccine. Minor/Significance Unknown. Effect of interaction is not clear, use caution. If coadministration of an NSAID is necessary, closely monitor patients for toxicity, especially myelosuppression, renal toxicity, and GI toxicity. Loffler W, Kilian R, Toumi M, et al. Minor/Significance Unknown. Concomitant administration may increase tacrolimus whole blood concentrations, particularly in intermediate or poor metabolizers of CYP2C19. Use Caution/Monitor. Modify Therapy/Monitor Closely. oxycodone and clomipramine both increase sedation. A number of color additives must be certified for purity in FDA labs if they are to be used legally in a product marketed in the United States. Modify Therapy/Monitor Closely. Use Caution/Monitor. Use Caution/Monitor. Immunosuppressants also increase risk of infection with concomitant live vaccines. voriconazole will increase the level or effect of tacrolimus by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. Use Caution/Monitor. Monitor Closely (1)tacrolimus decreases effects of influenza virus vaccine trivalent, recombinant by pharmacodynamic antagonism. Monitor Closely (1)oxycodone and moxonidine both increase sedation. Use Caution/Monitor. gentamicin and tacrolimus both increase nephrotoxicity and/or ototoxicity. elagolix decreases levels of methylergonovine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. The populations were adolescents aged 1318 years and adults aged 19 years or older. Monitor Closely (2)tacrolimus and eliglustat both increase QTc interval. Use Caution/Monitor. Use Caution/Monitor. Monitor closely for signs of respiratory depression and sedation. For 2 weeks after abametapir application, avoid taking drugs that are CYP3A4 substrates. Serious - Use Alternative (1)celecoxib increases levels of methotrexate by decreasing renal clearance. Effect of interaction is not clear, use caution. SSRIs inhib. Contraindicated. Monitor Closely (1)valbenazine and tacrolimus both increase QTc interval. Immune response to vaccine may be decreased in immunocompromised individuals. Minor/Significance Unknown. Minor/Significance Unknown. Accessibility Monitor Closely (1)primaquine and tacrolimus both increase QTc interval. Modify Therapy/Monitor Closely. Avoid or Use Alternate Drug. Monitor Closely (1)methylergonovine, loxapine inhaled. Mechanism: pharmacodynamic synergism. Nikolaus T, Kruse W, Bach M, et al. diltiazem will increase the level or effect of oxycodone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Monitor Closely (2)celecoxib decreases effects of celiprolol by pharmacodynamic antagonism. Monitor therapeutic drug concentrations and adjust the dose as needed. lumefantrine will decrease the level or effect of tacrolimus by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Unknown. Complex treatment is believed to threaten the patients compliance. Use Caution/Monitor. darifenacin will increase the level or effect of tacrolimus by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Comment: May result in renal function deterioration, particularly in elderly or volume depleted individuals. Use Caution/Monitor. Either increases toxicity of the other by Other (see comment). Use Caution/Monitor. Modify Therapy/Monitor Closely. ketamine and oxycodone both increase sedation. Use Caution/Monitor. Use Caution/Monitor. celecoxib, cyclosporine. Use Caution/Monitor. Immunosuppressants also increase risk of infection with concomitant live vaccines. Use Caution/Monitor. Effect of interaction is not clear, use caution. Crofelemer has the potential to inhibit CYP3A4 at concentrations expected in the gut; unlikely to inhibit systemically because minimally absorbed. As previously mentioned, if the patients do not follow or adhere to the treatment plan faithfully, the intended beneficial effects of even the most carefully and scientifically-based treatment plan will not be realized. Use Caution/Monitor. Coadministration with duvelisib increases AUC of a sensitive CYP3A4 substrate which may increase the risk of toxicities of these drugs. Sep. by 24h. Contraindicated. oxycodone and loxapine inhaled both increase sedation. Monitor Closely (1)azelastine and oxycodone both increase sedation. Use Caution/Monitor.Minor (1)celecoxib will increase the level or effect of indomethacin by acidic (anionic) drug competition for renal tubular clearance. Minor/Significance Unknown. Avoid or Use Alternate Drug. Your list will be saved and can be edited at any time. Monitor Closely (1)tipranavir will increase the level or effect of oxycodone by affecting hepatic enzyme CYP2D6 metabolism. Lastly, healthcare expenditure is a very important factor for patients with chronic diseases because the treatment could be life-long so the cost of therapy would constitute a large portion of their disposable income. Avoid coadministration with erdafitinib and sensitive CYP3A4 substrates with narrow therapeutic indices. Monitor for evidence of serotonin toxicity (eg, mental status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction). Serious - Use Alternative (1)meclofenamate, tacrolimus. Monitor Closely (1)dextromoramide and oxycodone both increase sedation. efavirenz increases levels of methylergonovine by decreasing metabolism. Use Caution/Monitor. If coadministration is unavoidable, monitor patients for loss of therapeutic effect of these drugs. Use Caution/Monitor. Feinstein S, Keich R, Becker-Cohen R, et al. Use Caution/Monitor. Monitor Closely (1)dabigatran and celecoxib both increase anticoagulation. Comment: Mixed opiate agonist/antagonists usually produce additive sedation with narcotics; however, in narcotic addicted pts., the antagonist activity may provoke withdrawal Sx. Separate by 2 hours. Monitor Closely (1)bemiparin and celecoxib both increase anticoagulation. Coadministration increases risk of CNS depression, which can lead to additive impairment of psychomotor performance and cause daytime impairment. Mechanism: pharmacodynamic synergism. Monitor Closely (1)encorafenib, tacrolimus. If not feasible, avoid use of abametapir. Immunosuppressive therapies, including irradiation, antimetabolites, alkylating agents, cytotoxic drugs, and corticosteroids (used in greater than physiologic doses), may reduce the immune responses to vaccines.

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